Review on RBC a natural model for avanced/ targeted drug delivery system for anti-cancer therapy: potential and challenges

Abstract

Red blood cell loaded therapeutic agents have been acknowledged because of its advantageous biologic properties. Among all the drug carriers, red blood cell is being a unique nano drug carrier and so considered as a vascular drug delivery system after surface modification. This review is based on anti-cancer drug carried by RBC and its tremendous potentials and promising feature for encouraging development for future drug delivery system. Hence, the resealed erythrocyte and camouflaged nanoerythrosomes are the engineered RBC particles which are considered as targeted chemotherapeutic drug carrier. This review is also focused on the comparison between cancer drugs loaded with RBC and other nano carriers. Furthermore, several successful clinical trials for drugs such as doxorubicin, daunorubicin, l-asparaginase, methotrexate, 5-fluorouracil are specifically focused in this review which are loaded into RBC as chemotherapeutic agent. However, few limitations and drawbacks are noticeable which need to be solved before loading drug into RBC.