Pharmacological treatment for epileptic seizures

Abstract

Epilepsy is a chronic neurological disorder that leads to uncontrollable recurrent seizures. This might occur either due to genetic or different environmental factors. Controlling epileptic seizures is of great challenge and so different antiepileptic drugs of generations first, second, third and so on were discovered throughout past few decades and are still under constant research. Drugs such as phenytoin, carbamazepine, ganaxolone, cannabidiol, lamotrigine, vigabatrin and many more were introduced under different generations. These drugs have different mechanisms of action such as enhancement of GABA action, inhibition of sodium channel and inhibition of calcium channel etc. Some of the newer AEDs are more emphasized and are under continuous research due to having fewer adverse effects that effectively control seizures accompanied by epilepsy.