Implication of chronic stress and Diabetes in Cerebrovascular Dysfunction: A review study

Abstract

The aim of the review was to explore the effects of chronic stress and diabetes in cerebrovascular dysfunction and neurological disorder. The evidence of involvement of hyperglycaemia induced oxidative stress was found to be prominent to cause complications like vascular inflammation, and neurovascular impairments. The active participation of different chemokine, transcription factors and biochemical pathways/mechanisms were studied to breakdown the cross-talk between diabetes and cerebrovascular dysfunction. Thus, the main objective of this review is to explain the significant relationship between diabetes and cerebrovascular dysfunction by explaining the various biochemical pathways. This will be an aid to identify the role of oxidative, reactive oxygen species and genetic errors in progression of various co-morbidities. A better understanding of the correlation of chronic stress and diabetes may suggest alternate approaches to the treatment of neurological disorders through pharmaceutical interventions. Furthermore, studying the process by which oxidative stress affects the cerebro-vasculature and blood-brain barrier are essential for evaluating antioxidant therapies.