Investigating the role of leptin receptor (Q223R) gene polymorphism in breast cancer development in Bangladeshi women: a case-control study

Abstract

Breast cancer is well recognized as a significant cause of death, and it is well established that there is a genetic element associated with the prognosis of the disease. This study’s objective is to examine the association between the LEPR Q223R polymorphism and the risk of developing in Bangladeshi women. In this study, PCR-RFLP method was carried out on 20 participants among them 10 breast cancer patients and 10 healthy control group, to examine the allele frequencies of the LEPR Q223R polymorphisms. The results were inclusive, while variations of the frequencies of the defendant genotypes were observed, those variations were not statistically significant in terms of the association between the single nucleotide polymorphism and the risk of developing breast cancer in the selected population. These findings contribute to the scientific fields of genetics and factors related to breast cancer, which emphasizes the need for larger projects and studies to confirm these findings in this project. Gaining a more comprehensive understanding of genetic variants in various populations is necessary for the advancement of treatment approaches focused preventative measures for breast cancer.