Treatment options of Parkinson’s disease: How far we are from the cure?

Abstract

Parkinson’s disease (PD) can be defined as a neurodegenerative disorder, which is associated with movement disorders and comprises of four prevalent cardinal indications, which are rigidity, bradykinesia, tremor and postural instability. During the progression of the disease, different movement and non-movement complications arise in patients. Different pharmacological and non pharmacological treatment interventions are accessible for the control of Parkinson’s disease. Levodopa, Dopamine receptor agonists, inhibitors of catechol-O-methyl transferase (COMT) and inhibitors of monoamine oxidase-b (MAO-B) are popular pharmacological treatment choices. The complications can be prevented through adjunctive therapy and recent discovered approaches has brought new dimension in the treatment process of this disorder. The aim of this review is to summarize and evaluate the existing literatures on treatment options of Parkinson’s disease and also to focus on the recent advanced that is still in clinical trials and the possibilities of cure of this neurodegenerative disease.