A review on the role of Myc and miRNA in Glioblastoma multiforme

Abstract

Glioblastoma multiforme (GBM) is known as one of the most belligerent and malignant brain tumors in adults. Among the four grades of brain cancers, the glioblastoma is considered as the most infiltrative one. GBMs account for 60%–70% of malignant glioma. The median survival period of patients with such types of cancers usually exceeds from one year to fifteen months after treatment. Scientists are now approaching toward alternative ways of treating glioblastoma permanently. Different types of microRNA (miRNA) and the Myc oncogene play a vital role in regulation of multiple downstream targets to bring about alterations in gene mutation, chromosomal stability and inflection of tumor growth. This review paper delineates the role of Myc and microRNA in metabolism of glucose and tumor growth. Along with the possible utilization of C-Myc and miRNA, and how C-Myc and miRNA can perform the role of biomarkers and therapeutic targets for glioblastoma multiforme.