Recent advances in the replacement of invasive method of protein drug delivery-a review

Abstract

In today’s era the necessity of non-invasive protein drug delivery is increasing day by day. Most of the global pharmaceutical companies are showing encouraging progress in alternative technologies rather than invasive delivery. Needle free delivery could aid improved safety and compliance to the diabetic patients, mass vaccination by increasing ease and speed of delivery, decreasing cost and reducing pain associated with protein drug delivery. This article include the development technologies in the last decade which brought limelight strategies that hold some promise to turn non-injectable way of protein drug delivery mainly insulin and vaccines from theory to reality. A rigorous research effort has been undertaken worldwide to replace the authentic invasive delivery. Several research has been carried out to focus on different routes. Oral delivery of protein drug through azometric group and nanotechnology provide desirable result. Aerosol technology for pulmonary route and micro needle, iontophoresis for transdermal route gives hope to the world health sector. Many work has also been carried out for rectal and ocular routes. This article summarizes all the recent work which have been done based on different routes to replace the invasive way of protein/peptide delivery.