A review: cell penetrating peptides-an advanced drug delivery system & therapeutic approach for the treatment of Cancer

Abstract

In recent years, medical science has acheived a lot of success in the field of treatment.Treating cancer sucessfully is one of them.But though having unimaginable success and advancement in the medical field the rate of death due to cancer is increasing day by day with a growing population. According to the World Health Organization there were about estimated 20 million new cancer cases and 9.7 million deaths in 2022. So it is very clear that conventional chemotherapy or cancer treatment requires more advanced aproaches in order to control this growing death rate due to cancer.Application of Cell Penetrating Petides is one of those approaches. One extremely promising method for intracellular medication delivery is the use of cell-penetrating peptides. Cancer therapy is a pertinent clinical use of cell-penetrating peptides. Both oligonucleotide-based treatments and traditional small-molecule medications might be more effectively treated by increasing their absorption in tumor cells using peptide-based delivery.The cancer applications of cell penetrating peptides as delivery systems are the main focus of this review; including various aspects of drug loading, cargoes, and delivery are covered along with techniques for targeted delivery,transducible agents coupled to cell-penetrating peptides, and activatable cell-penetrating peptide.Clinical limitations with strategies to overcome those and comparison with conventional treatment are also two important aspects of this review.