An in-silico based multi epitope vaccine construction of flagellin protein opposing Helicobacter Pylori bacteria (H. Pylori)

Abstract

Helicobacter pylori (H. pylori) bacteria is a gram-negative bacteria that has capability to cause serious disease in human stomach by leading into peptic ulcer, mucosal lymph tissue, stomach cancer. According to WHO, it became type I carcinogen bacteria which colonizes and affects gastric mucosa layer of the stomach. Available antibiotics drugs were effective but now-days growing resistance to this particular bacterium. Hence, for such emerging situation a vaccine will be much more effective against bacterium; more convenient and budget friendly option to sufferer. In this study, protein sequence is used with different epitopes of Helper T cells, cytotoxic T cells, B cells to predict multi epitope-based vaccine for protection by computational (immunoinformatics) method.