A review on dissolving microneedle mediated transdermal insulin delivery

Abstract

Microneedles (MNs) are microscopic applicators used to deliver vaccines or other drugs across various barriers. Whereas the most favorite use of MN is transdermal applications. Generally, four types of MN are present. These are solid MNs, hollow MNs, coated MNs and dissolvable MNs. They can deliver drugs through different mechanisms. The vision of this report was to create a dissolving MNs application system. By which way insulin loaded dissolving MNs were made on a chip. By this lesson we can gain optimal relative bioavailability for insulin delivery using a gelatin/CMC MNs patch in comparison with traditional hypodermic injection. It may be a satisfactory delivery device for those drugs which are employed for diabetes and these drugs are not permeable. By insertion tests on human cadaveric skin it is indicated that dissolving MNs could deal as proficient devices for transdermal drug delivery in medical use. Also, to get total absorption of insulin, two-layered dissolving MNs array chips were equipped and delivered to the abdominal skin of rats. Glucose levels of plasma were calculated for 6h. The relative pharmacological availability was determined by comparing the hypoglycemic effect which was attained after subcutaneous injection.