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    Qualitative and quantitative analysis of sildenafil in traditional medicines and dietary supplements
    (© 2014 Asian Journal of Pharmaceutical and Clinical Research) Podder, Ashis Kumar; Chakrobarty, Jayanta Kishor; Faroque, A. B. M.; Department of Pharmacy
    Objective: Use of traditional medicines as aphrodisiac and sex stimulant products is a common phenomenon worldwide as well as in our country. In addition to that, in the name of dietary supplements, a number of urban people are using these items as the source of their sex potential. These products ought to be responsible for raising several sexual violence and perversion in the society. That's why these products need to be tested whether they contain only natural ingredients or any other allopathic active pharmaceutical ingredients (APIs). Methods:High performance liquid chromatography was carried out using a C18 column with a mobile phase composed of (diluted sulfuric acid:acetonitrile=60:40) and detected at the wavelength of 290nm. Presence of sildenafil in the identified products was further confirmed by infrared (IR) spectroscopy. Results:In the study, found that 5 out of 25 traditional medicines and 7 out of 10 dietary supplements contain sildenafil. In addition to that 4 out of total 35 samples were found to contain sildenafil that was exceeding the highest dose (100mg per dosage unit) recommended by the manufacturer (Pfizer,UK) of the brand product ViagraTM. Notably noneof the samples were labelled to contain sildenafil. Conclusion:About 35% of the market samples were adulterated with sildenafil. The developed method is simple, precise, specific, accurate, robust, and cost-effective. Hence it can be used for qualitative and quantitative analysis of sildenafil in falsified market products.
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    A pragmatic approach to the analysis of a combination formulation
    (© 2016 Elsevier B.V.) Mubtasim, Noshin; Kabir, Eva Rahman; Podder, Ashis Kumar; Bhadra, Subrata; Department of Pharmacy
    The aim of the paper was to formulate a combined oral dosage form of rosuvastatin calcium and amlodipine besylate and to develop and validate an analytical method to be adopted for both routine quality control assay and in vitro dissolution studies of the formulation. The proposed combination formulation has shown compatibility with the chosen excipients, verified through FT-IR study. A novel gradient RP-HPLC method was developed and validated according to the ICH guideline which was found to be suitable for the simultaneous estimation of rosuvastatin calcium and amlodipine besylate from the formulation. The retention time of 2.7 and 6.08 min allows the analysis of large amount of samples with less mobile phase which makes the method economic. The dissolution profiles of both the drugs in different dissolution medium were encouraging which makes the combination formulation of rosuvastatin calcium and amlodipine besylate superior and effective in achieving patient compliance.