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Permanent URI for this collectionhttps://hdl.handle.net/10361/7141
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listelement.badge.dso-type Item , In vitro study on interaction of ketotifen fumarate with metformin hydrochloride(© 2011 Latin American Journal of Pharmacy, 2011) Sayeed, Mohammed Aktar; Hasan, S. M. Raquibul; Rana, Md Sohel; Department of PharmacyThe present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job's continuous-variation analysis and Ardon's spectrophotomeric measurement. Job's analysis indicated the formation of 1:1 complex between ketotifen fumarate and metformin hydrochloride at the studied pH values. On the other hand, the values of stability constants (between negative values and 1), as calculated from Ardon's plot, mean that the formation of complex due to interaction between the drugs is readily dissociable. Thus the findings of the study suggest that both drugs can be safely co-administered. However, further studies involving animal models are needed to ascertain the exact nature of interaction between them in vivo.listelement.badge.dso-type Item , Antibacterial, cytotoxic and antioxidant potential of methanolic extract of phyllanthus acidus L(© 2010 IJDDR, 2011) Rahman, Md. Mominur; Habib, Md. Razibul; Hasan, S. M. Raquibul; Rana, Md Sohel; Department of PharmacyThe objective of the present study was to evaluate antimicrobial, cytotoxic and antioxidant potential of methanol extract of fruit part of Phyllanthus acidus. Phytochemical screening showed evidence of glycoside, tannin and resin. Antimicrobial activity was evaluated using disc diffusion method against 13 pathogenic bacteria where in higher concentration the extract showed moderate to good zone of inhibition against B. megaterium and B. subtilis also with S. typhi and S. dysenteriae. In case of brine shrimp cytotoxicity assay, showed good result with LC50 value 4.46 μg/ml where as LC90 value was 70.79 μg/ml. Antioxidant activity was evaluated by using total flavonoid content determination assays, total antioxidant capacity, 1,1-diphenyl-2-picryl-hydrazil (DPPH) free radical assay, reducing power assessment, cupric ion reducing capacity assay (CUPRAC method). The extract showed moderate to good antioxidant activity in a dose dependent manner and found to contain flavonoid compounds. In DPPH radical scavenging assay IC50 value found 2063.42 μg/ml and compared to ascorbic acid with 52 μg/ml. The extract also showed good cupric ion reducing capacity. The results of the present study indicate that the extract possesses moderate to good antioxidant potential.