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Study on Salmonella Typhi-Isolation, characterization and immunological studies

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dc.contributor.advisor Choudhury, Dr. Naiyyum Arefin, K. M. Shamsul 2010-09-23T05:09:27Z 2010-09-23T05:09:27Z 2009 2009
dc.identifier.other ID 07176005
dc.description This thesis is submitted in a partial fulfillment of the requirement for the degree of Masters of Science in Biotechnology, 2009 en_US
dc.description Cataloged from PDF version of thesis report.
dc.description Includes bibliographical references (page 37-46).
dc.description.abstract Typhoid fever is one of the most common febrile illnesses and its real impact is difficult to estimate because the clinical picture is confused with other febrile infections. Various diagnostic techniques are used for clinical diagnosis of typhoid patients. Unfortunately no technique so far us'P for can be considered as gold standard as a diagnostic tool for typhoid fever. Widal test is widely used in the developing countries for the diagnosis of the typhoid fever; however, Widal test takes a longer time for diagnosis . having high proportion of false positive results which would complicate the treatment. Blood culture technique is limited due to the indiscriminate use of antibiotics and its utility is restricted due to low numbers of bacteria in blood. Antibodies in lymphocyte supernatant (ALS) assay has recently been developed and standardized for the diagnosis aj typhoid fever which is highly sensitive for detection of Salmonella Typhi infection at early stage. Comparison of ALS assay with blood culture and Widal test has been carried out and the method is sensitive and specific. AL$ able to confirm typhoid infection in 52% patients, whereas, blood culture test confirmed 13% and Widal test confirmed 44% patients to be positive on Salmonella Typhi. Using ALS assay typhoid fever was diagnosed and confirmed within 48 hrs of fever. ALS assay can be used for rapid diagnosis of typhoid fever. en_US
dc.description.statementofresponsibility K. M. Shamsul Arefin
dc.format.extent 51 pages
dc.language.iso en en_US
dc.publisher BRAC University en_US
dc.rights BRAC University thesis are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.title Study on Salmonella Typhi-Isolation, characterization and immunological studies en_US
dc.type Thesis en_US
dc.contributor.department Department of Mathematical and Natural Science, BRAC University M. Biotechnology

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