Role of Mesenchymal Stem Cells & MicroRNA in the treatment of Osteoporosis

Abstract

Osteoporosis is currently the most difficult and painful disease endangering the lifestyle of the geriatric population. Through the gradual degeneration of osteoblastic cell in various parts of the bones, osteoporosis has caused a massive healthcare problem and cost for a significant part of the world populace. Despite having conventional therapies, like bisphosphonates, the disease still has no sustainable treatment option because the conventional drugs only emphasize on preventing bone degradation, not bone regeneration. As such, increasing researches on regenerative treatment options are getting huge attention especially in mesenchymal stem cells and it’s relationship with microRNAs. This novel treatment techniques introduces a sustainable, cost efficient and long lasting options for the osteoporotic patients. As such, this review mainly focuses on the tonsil derived mesenchymal stem cell therapy along with the therapeutic effects of microRNA in order to examine whether their therapeutic and regenerative potential are truly an amazing alternative or not.