A short review on novel anti-malarial Heterocyclic aromatic therapeutic agents: synthesis, efficacy and effectiveness of potential drug candidates for malaria

Abstract

Malaria, a vector-borne parasitic tropical illness has exponentially become a major disease as well as life threatening if not treated with right medication. Elimination of malaria is firmly back as a mainstream policy but there are major challenges to resistance to artemisinin derivatives, their partner drugs and insecticides. This review article contains the new developments of antimalarial drugs containing heterocyclic and cyclic ring, their synthesis, efficacy as well as in vitro and in vivo studies. However, we also discuss about new anti-malarials which are already in clinical trial as wells as effective in mice study and they might be the potential drug candidate for the treatment of malaria in future. We hope that our study will provide the way for the therapeutic exploitation of various new anti-malarials as safe and effective drug candidate for malaria.