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dc.contributor.advisorRahman, Kazi Fatema
dc.contributor.authorEva, Israt Ara Jannat
dc.date.accessioned2023-01-18T09:50:46Z
dc.date.available2023-01-18T09:50:46Z
dc.date.copyright2022
dc.date.issued2022-04
dc.identifier.otherID 18146047
dc.identifier.urihttp://hdl.handle.net/10361/17764
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.en_US
dc.descriptionCataloged from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 36-49).
dc.description.abstractThe novel CRISPR/Cas system is an effective and widely used gene-editing tool that has created the opportunity to study gene function and understand the pathogenic mechanisms underlying various genetic disorders. It has uncovered the pathophysiology of several previously unsolved medical conditions and is currently an essential genome-editing tool being employed to develop new drugs and innovative gene therapies for potentially life-threatening diseases such as, cancer and Duchenne muscular dystrophy (DMD). The specificity, accuracy, high probability of successful outcomes, cost and time effectiveness of CRISPR/Cas systems have made it a reliable means to treat cancer and DMD over other previously used genetic modification tools. This review will discuss how CRISPR/Cas can be utilized to design in vivo and in vitro disease models, target cancer cells, and aid in the identification of novel drug targets to treat cancer and DMD patients.en_US
dc.description.statementofresponsibilityIsrat Ara Jannat Eva
dc.format.extent49 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectCRISPR/Cas9 mechanismen_US
dc.subjectIn vivo and in vitro modelingen_US
dc.subjectCRISPR/Cas9 deliveryen_US
dc.subjectMutation targeting in cancer and DMDen_US
dc.subjectChromosomal rearrangementen_US
dc.subjectMouse modelingen_US
dc.subjectOff-target limitationen_US
dc.subjectDMD mutation in human iPSCsen_US
dc.subjectMyoediting of DMDen_US
dc.subjectTherapeutic application of CRISPRen_US
dc.subject.lcshMolecular genetics
dc.subject.lcshMolecular genetics
dc.subject.lcshCancer--Treatment
dc.titleCRISPR: a revolutionary tool for modeling and treating cancer and Duchenne muscular dystrophyen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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