Bachelor of Pharmacy
http://hdl.handle.net/10361/3211
2024-03-29T05:00:11ZA review on antibiotic resistant bacteria found in Dhaka water supply
http://hdl.handle.net/10361/22303
A review on antibiotic resistant bacteria found in Dhaka water supply
Tabassum, Tasnim
The unsafe water supply of Dhaka city causes concern for public health. This review work aims to identify whether antibiotic resistant bacteria are available in Dhaka water supply. According to the collected 25 articles that is reviewed in this paper, Escherichia coli bacteria was isolated from tap water samples taken from several places in Dhaka city. They were characterized for their antibiotic resistance, pathogenic characteristics, and genetic diversity in order to gain a better understanding of the degree of the public health risk that is attributed to the supply water in Dhaka city. It was identified that there is a widespread presence of E. coli that is resistant to many antibiotics in the Dhaka public water supply. The distribution of antibiotic resistant bacteria through municipal water supplies poses a significant risk to the general population's health in urban settings.
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.; Cataloged from PDF version of thesis.; Includes bibliographical references (pages 27-29).
2023-05-01T00:00:00ZIn-vitro antioxidant and cytotoxicity screening of ethanolic extract of lagerstroemia thorelli (Lythraceae) leaves
http://hdl.handle.net/10361/22257
In-vitro antioxidant and cytotoxicity screening of ethanolic extract of lagerstroemia thorelli (Lythraceae) leaves
Tipu, Amir Hamja
"Substantial antioxidant activity of Lagerstroemia thorelli leaves extract was revealed in DPPH free radical scavenging assay with an IC50 value of 83.05085 μg/mL compared to that of 47.55245 μg/mL demonstrated by ascorbic acid. Besides, the total phenolic content test exhibited concentration of phenolic compounds in the extract to be 122.6309 mg/g GAE of dry extract. Afterwards, cytotoxicity of the extract was assessed in terms of LC50 value. During the brine shrimp lethality bioassay, cytotoxicity of the leaf extract was evaluated to be impotent based on the LC50 at 28861.40 μg/mL against that of 0.000145 μg/mL for vincristine sulfate. However, more advanced researches must be performed to discover other pharmacological properties of L.
thorelli. Conclusively, on the basis of the present preliminary study, it can be claimed that the profound antioxidant property can be utilized to treat many oxidative stress-associated diseases."
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.; Cataloged from PDF version of thesis.; Includes bibliographical references (pages 47-50).
2023-02-01T00:00:00ZA review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies
http://hdl.handle.net/10361/22256
A review of endocannabinoid system and its pharmacological role as a drug target for cancer therapies
Khan, MD Salehin
Cancer is a genetic disorder that causes uncontrolled cell proliferation and the cells are unable to maintain apoptosis which leads the cells to cross their natural boundaries. Treatment of this diseases requires a complex system of medicines for this purpose endocannabinoid system serves as a potential target for effective medicine development. Endocannabinoid system is homeostasis system present in mammalians. It comprises of endogenous and exogenous ligands, membrane bound receptors and degrading enzymes. The ligands of this system can be an effective molecule for drug development. Cannabinoid molecule can cause apoptosis in cancer cell through three different pathways they include JNK and p38 MAPK activation pathway, ceramide generating pathway and autophagy pathway. By modulating these pathways cannabinoid can be effective against various types of cancer cells. These molecules also have anti-inflammatory and analgesic properties and evidence shows that these properties can be useful in palliative care treatment with less side effects.
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.; Cataloged from PDF version of thesis.; Includes bibliographical references (pages 24-29).
2023-02-01T00:00:00ZEvaluation of anti-diarrheal activity of methanolic flesh extract of Flacourtia jangomas on mice
http://hdl.handle.net/10361/22255
Evaluation of anti-diarrheal activity of methanolic flesh extract of Flacourtia jangomas on mice
Susmita, Nusrat Jahan
"Flacourtia jangomas is rare fruit, rarely found in hill tracks of Bangladesh. This is a less
researched fruits but have many phytochemical constituent. It contain many pharmacological
activity as well. The fact that F. jangomas is now thought to be an excellent reservoir of
chemicals such phenol, tannin, alkaloids, flavanoids, and terpenoids that may be a better source
to cure diarrhea is a major driving force behind this research. This study tested the F. jangomas
flesh in vivo antidiarrheal effect on Swiss albino mice. In order to compare the test results,
Loperamide was utilized as the reference medication. Three concentrations of F. jangomas
(15mg/ml, 30mg/ml and 45mg/ml) of each extract showed antidiarrheal activity. The results
have been elucidated as number of feces in every 1hr. The number feces counted till 4hrs. The
antidiarrheal activity of methanolic flesh per hour until 4hrs extract of F.jangomas at
100,200and 300mg/kg concentration showed number of feces time respectively is 10.83, 9.67
and 8.65 in 4hrs. F. jangoma showed the effectiveness of antidiarrheal activity 14.52%,
23.68%and 32.91% respectively. All the result were significant (P<0.001) for the antidiarrheal
activity. This study highlights the significance of F. jangomasin's use as an antidiarrheal agent
and the need for additional research to identify the active ingredient that causes this effect."
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.; Cataloged from PDF version of thesis.; Includes bibliographical references (pages 34-36).
2022-11-01T00:00:00Z