Sheikh, ZaraNabila, Morshed2016-12-032016-12-032014Sheikh, Zara, & Nabila, M. (2014). Optimizing Oral Drug Delivery using Lipid based Formulations. International Research Journal of Pharmacy, 05(07). doi:10.7897/2230-8407.05071052230-8407http://hdl.handle.net/10361/7088This article was published in International Research Journal of Pharmacy [© 2014 International Research Journal of Pharmacy] and the definite version is available at: https://goo.gl/TTYiEn The Article's website is at: www.irjponline.comA great challenge facing the pharmaceutical scientists is transforming the new pharmacologically active lipophilic compounds that are poorly water soluble into orally administered medications with sufficient bioavailability. Lipid-based drug delivery systems has shown a great potential in the oral delivery of poorly water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed products. Oral lipid-based formulations comprises of a broad range of oils, surfactants, and co-solvents. This review provides a comprehensive summary of the development, characterization, and utilization of oral lipid- based formulations, from both physicochemical and biopharmaceutical perspectives. The properties of the various lipid excipients are discussed and the criteria for selection of excipients for lipid-based formulations are identified. Finally the future prospects of this technique have been addressed to expand the utility of lipid based drug delivery systems.enOral drugLipid based formulationsLipid excipientsCharacterizationArticlehttp://doi.org/10.7897/2230-8407.0507105