Sayka Khan, Tanisha TabassumSadia, Mir2022-10-182022-10-1820222022-02ID: 18146057http://hdl.handle.net/10361/17517Cataloged from PDF version of thesis report.Includes bibliographical references (pages 61-68).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.Cancer is one of the leading causes of death around the world. The ability to proliferate at a rapid rate, metastasize, and form heterogeneous tumors due to mutagenic occurrences renders cancer as one of the most difficult-to-treat diseases in the world. Owing to its high accuracy and efficiency, the gene editing tool Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and CRISPR-associated (Cas) enzymes have shown immense potential in the treatment of genome-based diseases, especially cancer. The ability to deliberately activate or repress genes, allows CRISPR-Cas systems to discover novel targets for new potential anti-cancer drugs. In this review, the mechanism of different classes of CRISPR-Cas systems are summarized. Several other applications including diagnostic and therapeutic applications of CRISPR-Cas systems in the field of oncology are also addressed in this review.68 Pagesen-USBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.CRISPR-CasCancer treatmentImmunotherapyCRISPR applicationsDisease modelsOncologyGenetic engineeringGene editing--Technological innovations.CRISPR-associated protein 9.Thesis