Omer, Humair Bin Md.Islam, Mohammad Saiful2025-09-112025-09-1120252025-03ID 18146019http://hdl.handle.net/10361/26704Cataloged from PDF version of thesis.Includes bibliographical references (pages 55-59).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2025.The peroxisome proliferator activated receptors (PPAR) are members of nuclear receptor supergene family that play a vital role in both glucose and lipid homeostasis. Thiazolidinediones (TZDs) has high affinity to PPAR- receptors. But TZD scaffolds in antidiabetic drugs is responsible for fluid retention, weight gain, bone fractures, liver failure, hypoglycemia and allergic skin reaction. Investigators are searching for novel antidiabetic drugs with higher affinity and minimum side effects. Nowadays. phytochemicals are becoming promising compounds for health benefits. In this study, 11 limonoids (non-TZD) nomilin, obacunone, obacunoic acid, ichagin, limonite A- ring lactone, limonin, calamine, cyclocalamin, limonol, limonin and 17-beta-D-glucopyranoside have been analyzed via docking studies. Among them obacunone, limonite-A- ring lactone, nomilin. 7-alpha obacunol and limonol have demonstrated good binding affinity with PPAR- γ receptor that are promising lead antidiabetic compounds.59 pagesenBRAC University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.LimonoidsPPAR receptorThiazolidinedionesMolecular dockingInsulin resistancePharmacokinetic analysisPharmacokinetics.Limonoids.Botanical chemistry.Diabetes Mellitus.Insulins--pharmacology.Molecular pharmacology.Thesis