Kabir, Md. TanvirMithila, Sabekun Nahar2023-04-032023-04-0320222022-02ID: 17146031http://hdl.handle.net/10361/18064Cataloged from PDF version of thesis.Includes bibliographical references (pages 39-48).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.In current therapy for controlling peripheral nervous system disorders, one of the milestones is the voltage-gated sodium channel modulators. They have higher efficacy with improved side effects. They target the channel and their different subunits to modify the nerve impulse by allowing sodium ions. Selective drugs and biological products are used as modulators to limit the negative effects of disorders. Some drugs may either activate or deactivate the channels by altering the voltage-gated sodium channels pore. Moreover, biological products like alkaloids, marine toxins have a crucial role in understanding binding sites with actions on the sodium channel. Researchers are investigating numerous isoform-selective drugs in treating peripheral nervous system-related disorders. In this report, detailed information about the modulator's ongoing research on the active field is also elucidated.48 pagesenBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.VGSCPeripheral nervous system disordersVoltage-gated sodium channel modulatorsMarine.Nervous system--Diseases.Thesis