Omer, Humair Bin Md.Shuvo, Partho Saha2024-09-012024-09-01©20232023-12ID 19346003http://hdl.handle.net/10361/23953Cataloged from the PDF version of thesis.Includes bibliographical references (pages 42-48).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.A higher force that blood applies to artery walls is characteristic of hypertension, known as high blood pressure. Calcium channel blockers (CCBs) treat hypertension via specifically blocking voltage-gated calcium channels found in the smooth muscle cells of the arterial walls. CCBs prevent calcium ions from entering these cells which relaxes the arterial smooth muscle cells and widens the blood vessels. DHP-CCBs e.g. amlodipine and nifedipine are the most frequently suggested CCBs because they are well-tolerated, have few adverse effects, and effectively control blood pressure. Diltiazem and verapamil, two non-DHP-CCBs are alternative therapies used to treat hypertension, angina and arrhythmias and block calcium channels in the heart, causing a heart rate and contractility drop. This review article covers mechanism of action, synthesis and SARs of CCBs. It aims to assist medicinal chemists in the field of developing new antihypertensive agents through presenting recent information on producing CCBs and their synthetic techniques in the literature.57 pagesenBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.Anti-hypertensive drugsCalcium channelCCBsDHPHypertension--ChemotherapyHypotensive agentsCalcium--Antagonists--Therapeutic useThesis