Omer, Humair Bin MdMim, Md. Rasel Mahmud2024-06-042024-06-04202320232023-02ID 19146081http://hdl.handle.net/10361/23114Cataloged from the PDF version of thesis.Includes bibliographical references (pages 59-66).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.Nebivolol is a potent beta-blocker used to treat heart failure and hypertension. With the increasing prevalence of cardiovascular diseases and the demand for effective and well-tolerated treatments, the global market for beta-blockers, including nebivolol, was worth approximately US$8.5 billion in 2020 and is projected to grow by 5.5% in the coming years. There are several techniques for synthesizing nebivolol, including Sharpless asymmetric epoxidation, Pd-, Zr-, and Mo-catalyzed processes, photochemical reconfiguration, and homochiral sulfoxide-directed reaction (Jiang et al., 2021). Among these techniques, Zr- and Mo-catalyzed processes produce the highest efficiency of 99%. However, using natural chiral starting materials and Sharpless asymmetric epoxidation is more efficient in terms of time and cost. This review article provides an in-depth analysis of the effectiveness of the various nebivolol synthesis techniques. The commercial expansion of beta-blockers and the rising need for efficient and well-tolerated medicines emphasize how critical it is to conduct further research in this area.66 pagesenBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.Sharpless asymmetric epoxidationAsymmetric dihydroxylationChiral photochemical synthesisHypertension.Thesis