Ahmed, SohelHossain, MehrinChakrabortty, DeepitaArafat, Kazi IfthiHosen, Mohammad JakirKhan, Mohammad Mizanur Rahman2026-07-202026-07-202023-12-01Ahmed, S., Hossain, M., Chakrabortty, D. et al. Impacts of vitamin C and D supplement on COVID-19 treatment: possible patho-mechanisms and evidence from different countries. Egypt J Bronchol 17, 13 (2023). https://doi.org/10.1186/s43168-023-00186-6168784262-s2.0-105018836794https://hdl.handle.net/10361/28610Background: A balanced diet and nutrition greatly influence our immune system’s ability and regulate the risk and severity of infections. This review presented the possible patho-mechanisms of vitamins C and D in COVID-19 immunity. Main body: Deregulation of the immune system including the decreased level of immune boosters is invariably reported in COVID-19. Vitamin C and vitamin D are among the immune boosters; homeostasis of those was found essential for fighting against the viruses, and COVID-19 is no exception. Statistical data strengthens the statements put forth on the effects of these vitamins regarding the complications, symptoms, and mortality. Short conclusion: A comprehensive literature review revealed that vitamin C helps to reduce and in some cases eradicate the particular symptoms that pose major risks of COVID-19 while balanced vitamin D content in COVID-19 patients has been proved to possess a negative correlation with mortality. © The Author(s) 2023.6 pagesen-UStrueCOVID-19MechanismSARS-CoV-2TreatmentVitamin CVitamin DCOVID-19 (Disease)--Treatment.Vitamin C--Therapeutic use.Vitamin D--Therapeutic use.Dietary supplements--Therapeutic use.Article10.1186/s43168-023-00186-6