Asaduzzaman, MuhammadIslam, Ferdousi2025-01-122025-01-12©20242024-09ID 20346029http://hdl.handle.net/10361/25104Cataloged from PDF version of thesis.Includes bibliographical references (pages 50-52).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.The research identified and analyzed genes related to the STAT3 pathway, which plays a crucial role in lung adenocarcinoma progression and treatment resistance. Thus, using BioPortal, Harmonizome, and KEGG PATHWAY several genes including HRAS, SMAD2, IQGAP1, and NFKB1 were considered as significantly co-expressed with STAT3. These genes were also reported to affect different cancer pathways, which are Ras, TGF-beta and NF-kappa B signaling all of which are core to cancer cell proliferation and survival. The pathway analysis of STAT3 target genes demonstrated that the TGF-beta signaling and MAPK signaling pathways are most relevant to lung cancer cases proving their key role in STAT3 mediated tumorigenesis. These findings also point to possible new therapeutic targets to improve the treatment of lung adenocarcinoma, because the pathways detected could represent avenues for molecular therapies that the current standard treatment of chemotherapy and radiation does not fully address, and are likely to provide better survival outcomes.65 pagesenBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.Lung adenocarcinomaSTAT3 pathwayMAPK signalingTGF-beta signalingLung cancerMolecular pathwaysLungs--Cancer--Therapy.Bioinformatics.Thesis