Chowdhury, Namara MariamChowdhury, Saadia Shams2024-04-242024-04-2420222022-09ID: 18346063http://hdl.handle.net/10361/22662Cataloged from PDF version of thesis.Includes bibliographical references (pages 29-35).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.The aim of this study was to use a solid-self emulsifying drug delivery system (S-SEDDS) to increase the solubility and dissolution rate of Domperidone (DMP), a poorly soluble, weakly basic anti-emetic medication. Several ratios of Kollisolv, Kolliphor® P188, and Glycerin were trialed and an S-SEDDS-DMP was formulated using the optimized ratio. Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Powder Diffraction (XRPD), Fourier-transform infrared spectroscopy (FT-IR), and in-vitro dissolution rate experiments were used to characterize the S-SEDDS-DMP. The lack of incompatibilities between DMP and the utilized polymers was established by FT-IR and DSC tests. DSC, SEM, and XRPD analyses demonstrated that the drug in the produced S-SEDDS changed from crystalline to amorphous. It may be stated that the S-SEDDS approach was a successful tool for improving DMP dissolution.35 pagesenBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.DomperidoneSolubilitySolid self-emulsifying drug delivery system (SSEDDS)BioavailabilityDissolutionBCS Class II drugDrug carriers (Pharmacy)Thesis