Siam, Mohammad Kawsar SharifSiddika, Samira2024-10-012024-10-01©20242024-04ID 20146058http://hdl.handle.net/10361/24264Cataloged from PDF version of thesis.Includes bibliographical references (pages 37-39).This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.Hantavirus is a zoonotic virus which is responsible for causing hemorrhagic fever with renal syndrome & hantavirus pulmonary syndrome. But still, there is no stable vaccine developed for this virus. Developing a multiepitope vaccine candidate against this virus was the main concern of this study by using immune-informative approach. Different computational tools were used to identify the CTL, HTL & B cell epitopes for envelope surface glycoprotein. Various linkers were used to connect the epitopes with the adjuvant and construct the candidate vaccine. Physicochemical properties like - molecular weight, instability index, aliphatic index, GRAVY was also checked for the prepared vaccine. Molecular docking was done with toll-like receptor 4 (TLR-4) for checking the residual interaction. And lastly, C-ImmSim was used to evaluate the immune stimulation. Further investigation is needed to check the safety and efficacy of this vaccine candidate because checking safety & efficacy is not a part of in-silico study.51 pagesenBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.HantavirusEnvelope glycoproteinHTLCTLB cellIn-silicoHantavirus infections--Prevention.Hantaviruses--Vaccines.Thesis