Islam, Md. RabiulHasan, Sarder Mostakim2026-09-022026-09-0220262026-05ID 22146088https://hdl.handle.net/10361/29707This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2026.Cataloged from PDF version of thesis.Includes bibliographical references (pages 44-46).Major Depressive Disorder (MDD) is a disease of complex biological origin, including much more than personality or a mere imbalance of neurotransmitters. More recently, there has been a growing appreciation that immune dysregulation, specifically interleukins, plays an important part in its pathophysiology. In addition to that, the function of these interleukins is not limited to neurotransmitter metabolism via the kynurenine pathway but may also affect neuroplasticity by means of activating the HPA axis due to decreased BDNF levels. Besides, interleukins can serve as markers of the severity and treatment efficacy of the disease. As for treatments based on targeting inflammation, they proved themselves very promising, especially when the disorder is treatment-resistant.46 pagesen-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalBRAC University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.http://creativecommons.org/licenses/by-nc-nd/4.0/Major Depressive DisorderInterleukinsNeurotransmittersImmune dysregulationPathophysiologyMetabolismInflammationNeuroplasticityDepression, Mental.Neuroplasticity.Neurotransmitters.Physiology, Pathological.Interleukins.Thesis