Comparative study of complement protein activity of blood serum against escherichia coli in urban and slum population of Bangladesh

Abstract

The complex of serum proteins known as complement plays key roles in the lytic and inflammatory properties of the immune system, including both innate and adaptive immunity. The last several years have seen an enormous expansion in our understanding of the details of complement biochemistry and in our appreciation of the role of complement proteins in biological phenomena. This observation particularly calls for the in vitro examination of complement proteins activity derived from blood serum of a defined group of urban and slum people against E. coli, a major cause of large scale epidemics and thousands of sporadic cases of gastrointestinal illness. In this exertion we attempt to make a comparative analysis on complement mediated killing of clinical isolates of E. coli, derived from serum collected from urban and slum population. However the slum population showed more effective complement mediated killing in comparison to urban population.