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Safety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistance

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bracu.degree.levelUndergraduate
bracu.type.groupStudent Works
datacite.rightsOpen Access
dc.contributor.advisorHossain, Mahboob
dc.contributor.authorHossain, Sayema Syeda
dc.contributor.departmentDepartment of Mathematics and Natural Sciences
dc.date.accessioned2021-03-08T04:10:38Z
dc.date.available2021-03-08T04:10:38Z
dc.date.copyright2020
dc.date.issued2020-02
dc.descriptionThis thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Science in Microbiology, 2020.en_US
dc.descriptionCatalogued from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 50-55).
dc.description.abstractCitrobacter freundii is a species of bacteria in the Enterobacteriaceae family that is known to cause hospital-acquired infections in the respiratory tract, urinary tract, blood, and other normally sterile sites in immunocompromised patients and is growing resistant to multiple antibiotics. In the current state of growing antibiotic resistance, phage therapy is one of the alternatives being explored. Two of the biggest concerns regarding phage therapy are the virus' ability to transfer antibiotic resistance or virulence genes through phage morons. After comparison using Linux based BLAST between complete Citrobacter phage genomes downloaded from the NCBI website and the Comprehensive Antibiotic Resistance Database and the Virulence Factor Database, it was determined that none of the 21 phages showed signs of carrying virulence or antibiotic resistance genes. Through phylogenetic tree construction using Linux based Roary and web-based ITOL, it was determined that there is a possibility of lysogeny in the phagesen_US
dc.description.degreeBachelor of Science in Microbiology
dc.description.statementofresponsibilitySayema Syeda Hossain
dc.format.extent55 pages
dc.identifier.otherID: 13226005
dc.identifier.urihttp://hdl.handle.net/10361/14321
dc.language.isoen_USen_US
dc.publisherBRAC Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectBacteriophagesen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectCitrobacter freundiien_US
dc.titleSafety Assessment of Citrobacter freundii Bacteriophages for Use in Phage Therapy in the Face of Antibiotic Resistanceen_US
dc.typeThesisen_US

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Thesis (Bachelor of Science in Microbiology)