The combination of bacteriophage therapy and antibiotic therapy

Abstract

Antibiotic resistance has become a major problem of current time. A lot of deadly bacterial pathogens have become resistant to antibiotics. In addition, pathogens like P.aeruginosa, E.coli, Acinetobacter baumannii and many other bacteria has strains which are resistant to multiple antibiotics. This has made these pathogens even more deadly. Also the overuse of antibiotics is harmful for human health. Thus this indicates to choose an alternative. However, the bacteriophage therapy could be a great and effective alternative. This review paper contains the effectiveness of the combined treatment of bacteriophage and antibiotics against deadly pathogens which have also become resistant to multiple drugs as well. Bacteriophages are viruses which infect and replicates within the specific bacterial cell. The phage virus is highly specific. This indicates that the phage virus will only infect the targeted bacterial pathogen and would not harm the surroundings. The combination of phage therapy with antibiotic therapy has showed positive results in many cases. Multiple experiments have showed significant success by using the combined therapy. The success rate of this combined treatment against pathogens like P.aeruginosa, E.coli or Acinetobacter baumannii and their multiple resistant strains is very promising. Although a lot of experiments should be done to achieve better results in this field.