Inducible Clindamycin resistance among clinically isolated Methicillin resistant Staphylococcus aureus (MRSA) at tertiary care hospitals in Bangladesh

Abstract

Upon being virtually resistant to all β lactam antibiotics, Methicillin Resistant Staphylococcus aureus (MRSA) infections are being commonly treated by clindamycin due to various benefits. But due to the inducible Macrolide Lincosamide Streptogramin B (MLSB) phenotype, clindamycin is no longer effective. The research aimed to explore different methods to find the prevalence of MRSA and observe the inducible clindamycin resistance (iCR) in S. aureus isolated from clinical samples. By analyzing 45 isolates from wound and blood samples across various hospital departments, the research confirmed 31 (68.9%) MRSA strains via cefoxitin disk diffusion, including a notable prevalence of the mecC gene in 8 isolates. The study also reports iCR through D-tests, revealing that 64.4% of the S. aureus isolates exhibited inducible clindamycin resistance, with a higher occurrence in MRSA than MSSA strains. This highlights the urgency of continued surveillance and advanced molecular techniques to better understand and combat clindamycin resistance in MRSA.