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Antidiarrheal, antioxidant and antimicrobial activities of the musa sapientum seed

Show simple item record Hossain, M Sarowar Alam, M Badrul Asadujjaman, M Zahan, Ronok Islam, M Monirul Mazumder, M Ehsanul H Haque, Md Ekramul 2016-12-07T06:33:43Z 2016-12-07T06:33:43Z 2011
dc.identifier.citation Sarowar Hossain, M., Badrul Alam, M., Asadujjaman, M., Zahan, R., Monirul Islam, M., Mazumder, M. E. H., & Haque, M. E. (2011). Antidiarrheal, antioxidant and antimicrobial activities of the musa sapientum seed. Avicenna Journal of Medical Biotechnology, 3(2), 95-105 en_US
dc.identifier.issn 20082835
dc.description This article was published in Avicenna Journal of Medical Biotechnology [© 2011, Avicenna Journal of Medical Biotechnology] and the definite version is available at: en_US
dc.description.abstract Musa sapientum (M.sapientum) commonly known as 'banana' is widely used in Bangladeshi folk medicine for the treatment of various ailments including diarrhea. Hence, the present study was designed to investigate antidiarrheal, antioxidant and antibacterial potential of the methanolic extract of M.sapientum seed (MMSS). The extract was studied for antidiarrheal property using castor oil and magnesium sulfate induced diarrheal model and charcoal induced gastrointestinal motility test in mice. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as nitric oxide (NO) and assessment of reducing power were used to evaluate antioxidant potential of MMSS. In addition, disc diffusion methods were used for antibacterial assay using various diarrheal induced bacterial strains. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. At the same doses, the extracts significantly (p<0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. In DPPH and NO scavenging method, MMSS showed good antioxidant potentiality in a dose dependent manner with the IC50 value of 12.32±0.33 μg/ml and 18.96±1.01 μg/ml, respectively with a significant (p<0.001) good reducing power. The extract also displayed strong antibacterial effect against when tested against Escherichia coli, Shigella dysenteriae, and Pseudomonas aeruginosa. Altogether, these results suggest that the MMSS could be used as a potential antidiarrheal agent along with its antioxidant and antibacterial potentiality. en_US
dc.language.iso en en_US
dc.publisher © 2011, Avicenna Journal of Medical Biotechnology. en_US
dc.subject Antibacterial agents en_US
dc.subject Diarrhea en_US
dc.subject Free radicals en_US
dc.subject Musa sapientum en_US
dc.title Antidiarrheal, antioxidant and antimicrobial activities of the musa sapientum seed en_US
dc.type Article en_US
dc.description.version Published
dc.contributor.department Department of Pharmacy, BRAC University

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