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dc.contributor.authorZahan, Ronok
dc.contributor.authorAlam, Md. Badrul
dc.contributor.authorIslam, Saiful
dc.contributor.authorS. Chowdhury, Nargis
dc.contributor.authorB. Hosain, Salman
dc.contributor.authorMosaddik, Ashik
dc.contributor.authorJesmin, Mele
dc.contributor.authorHaq, M. Ekramul
dc.date.accessioned2016-12-06T06:33:27Z
dc.date.available2016-12-06T06:33:27Z
dc.date.issued2011-03
dc.identifier.citationZahan, R., Badrul Alam, M., Saiful Islam, M., Sarker, G. C., Chowdhury, N. S., Hosain, S. B., . . . Ekramul Haque, M. (2011). Anticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing mice. International Journal of Cancer Research, 7(3), 254-262. doi:10.3923/ijcr.2011.254.262en_US
dc.identifier.issn18119727
dc.identifier.urihttp://hdl.handle.net/10361/7121
dc.descriptionThis article was published in International Journal of Cancer Research [© 2011 Academic Journals Inc.] and the definite version is available at : http://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdfen_US
dc.description.abstractThe research study was conducted to determine the antitumor effect of the flower of Alangium salvifolium (crude extract and diethylether fractions) against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 10 mg kg-1 body weight intraperitoneally. Extract/fractions was administered for nine consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. Significant (p<0.001) increases of survival times 30±0.96 and 25±0.40 days for crude extract and diethylether fraction of the A. salvifolium (10 mg kg-1) treated tumor bearing mice, respectively were confirmed with respect to the control group (20±0.13 days). The extract/fraction also decreased the body weight of the EAC tumor bearing mice. Hematological studies reveal that the heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to near normal levels was observed in extract treated animals. There was a significant (p<0.001) decrease in RBC count and increase in WBC counts in extract/fraction treated animals when compared to EAC treated animals. From the result it was showed that the extract has significant anticancer activity and that is comparable to that of Bleomycin.en_US
dc.language.isoenen_US
dc.publisher© 2011 Academic Journals Inc.en_US
dc.relation.urihttp://scialert.net/qredirect.php?doi=ijcr.2011.254.262&linkid=pdf
dc.subjectAlangium salvifoliumen_US
dc.subjectAnticanceren_US
dc.subjectEhrlich ascites carcinomaen_US
dc.subjectHematological profileen_US
dc.subjectMean survival timeen_US
dc.titleAnticancer activity of alangium salvifolium flower in ehrlich ascites carcinoma bearing miceen_US
dc.typeArticleen_US
dc.description.versionPublished
dc.contributor.departmentDepartment of Pharmacy, BRAC University
dc.identifier.doihttp://doi.org/10.3923/ijcr.2011.254.262


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