Characterization of phytoconstituents and potential bioactivity of Annona reticulata L. leaf extract
Date
2016Publisher
© 2016 Journal of Pharmacognosy and PhytochemistryAuthor
Shahriar, MohammadKhair, Nishat Zareen
Sheikh, Zara
Chowdhury, Sayeeda Fahmee
Kamruzzaman, Md.
Bakhtiar, Md. Shawkatul Islam
Chisty, Sharmin Jahan
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1. Shahriar M, Khair N.Z, Sheikh Z, Chowdhury S.F et al (2016). Characterization of phytoconstituents and potential bioactivity of Annona reticulata L. leaf extract. Journal of Pharmacognosy and Phytochemistry, 5(1): 42-45Abstract
Annona reticulata
(Annonaceae) is known as atafol in Bangla and custard apple in English is an important medicinal plant. It has been used traditionally in diarrhea, dysentery, cold, as abortifacient, insecticidal drug etc.
In this present study, the leaf extracts of
Annona reticulata
were subjected to evaluation of the thrombolytic activity was assessed by using human erythrocyte and the results were compared with standard streptokinase (SK). The chloroform extract showed 36.82% clot lysis as compared to 93.79% clot lysis produced by standard streptokinase. The leaf extracts of
Annona reticulata
were subjected to evaluation of the membrane stabilizing activity by using human erythrocyte and the results were compared with standard anti-inflammatory drug, acetyl salicylic acid (ASA).
In vitro
membrane stabilizing activity for hypotonic solution induced haemolysis, the chloroform extract inhibited 75.15% haemolysis of RBCs as compared to 72.99% produced by acetyl salicylic acid (ASA) and during heat induced condition different organic soluble materials of
Annona reticulata
demonstrated methanol, ethanol and chloroform extract showed 68.81%, 72.06% and 78.17% inhibition of RBC hemolysis respectively whereas standard acetylsalicylic acid showed 70.87% inhibition of RBC haemolysis.
Keywords
Annona reticulate; Leaf extract; Phytoconstituents; Membrane stabilizing; Thrombolytic activityDescription
This article was published in the Journal of Pharmacognosy and Phytochemistry [©2016 Journal of Pharmacognosy and Phytochemistry]Department
Department of Pharmacy, BRAC UniversityType
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- Article [8]
- Faculty Publication [7]