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dc.contributor.authorAlam, Badrul
dc.contributor.authorHaque, Ekramul
dc.date.accessioned2016-12-01T09:31:13Z
dc.date.available2016-12-01T09:31:13Z
dc.date.issued2011
dc.identifier.citationAlama, B., & Haque, E. (2011). Anti-alzheimer and antioxidant activity of celastrus paniculatus seed. Iranian Journal of Pharmaceutical Sciences, 7(1), 49-56en_US
dc.identifier.issn17352444
dc.identifier.urihttp://hdl.handle.net/10361/7064
dc.descriptionThis article was published in Iranian Journal of Pharmaceutical Sciences [© 2011 Iranian Journal of Pharmaceutical Sciences] and the definite version is available at : http://en.journals.sid.ir/ViewPaper.aspx?ID=229292 The article website is at: http://en.journals.sid.ir/JournalList.aspx?ID=4452en_US
dc.description.abstractThe crude methanolic extract of the seeds ofCelastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and antialzheirmer (AD) activity. The extracts showed prominent DPPH free radical scavenging activity, inhibiting activity of authentic peroxynitrite (ONOO-) and inhibition of total reactive oxygen species (ROS) generation. In DPPH radical scavenging assay, the EtOAc fraction showed the highest activity with a IC50 value of 25.92±1.02 mg/ml whereas aqueous fractions had no activity at all within the tested concentration. Scavenging of the authentic ONOO- system, all extract/fractions showed good activity and among them, EtOAc fraction had the highest activity with a IC50 value of 15.79±0.18 mg/ml. EtOAc fraction also showed significant (p<0.001) inhibitory activity against the total ROS generation which was almost similar with that of the positive control Trolox (IC50 16.79±0.19mg/ml). All extract/fractions exhibited statistically significant (p<0.001) cholinesterases (ChEs) inhibitory effects with IC50 values ranging between 134.7-227.5 mg/ml for AChE and 209.6-562.1 mg/ml for BChE.en_US
dc.language.isoenen_US
dc.publisher© 2011 Iranian Journal of Pharmaceutical Sciencesen_US
dc.relation.urihttp://www.sid.ir/en/VEWSSID/J_pdf/106720110108.pdf
dc.subjectAnti-alzheimeren_US
dc.subjectAntioxidanten_US
dc.subjectCelastrus paniculatusen_US
dc.subjectCholinesteraseen_US
dc.subjectROSen_US
dc.titleAnti-alzheimer and antioxidant activity of celastrus paniculatus seeden_US
dc.typeArticleen_US
dc.description.versionPublished
dc.contributor.departmentDepartment of Pharmacy, BRAC University


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