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    Anti-inflammatory and anti-diarrheal effects of methanolic extracts of seeds and peel of Nephelium longan fruits in rats

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    Date
    2013
    Publisher
    © 2013 Iranian Journal of Pharmacology and Therapeutics
    Author
    Ripa, Farhana Alam
    Habib, Afroza
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10361/6976
    Citation
    Ripa, F. A., & Habib, A. (2013). Anti-inflammatory and anti-diarrheal effects of methanolic extracts of seeds and peel of nephelium longan fruits in rats. Iranian Journal of Pharmacology and Therapeutics, 12(2), 58-61.
    Abstract
    Herbal medicines are playing a vital role in the remedy of numerous diseases. Preliminary phytochemical screening of the methanolic extracts of seeds (MNLS) and peel (MNLP) of Nephelium longan revealed the presence of alkaloids, tannins and flavonoids. For antidairrheal screening, we have followed Castoroil- induced method whereas to check anti-inflammatory property, we used carrageenan-iduced rat paw edema in Long-Evan rats. Two doses (250 and 500 mg/Kg) of the extracts and one dose of indomethacin as reference was used. Both extracts significantly (p < 0.05) reduced the formation of oedema induced by carrageenan in a dose-depending manner. MNLP and MNLS also exhibited anti-diarrheal action in dosedepending manner and all the results were found to be significant (p < 0.05) in comparison to loperamide. The outcomes indicate the potent anti-inflammatory and anti-diarrhoeal effects of N longan extracts on living models which are comparable with those of standard drugs such as indomethacin and loperamide respectively and support their conventional uses as medicine.
    Keywords
    Anti-diarrhoeal activity; Anti-inflammatory; Nephelium longan
     
    Description
    This article was published in Iranian Journal of Pharmacology and Therapeutics [© 2013 Iranian Journal of Pharmacology and Therapeutics] and the definite version is available at: http://ijpt.iums.ac.ir/index.php/ijpt/article/view/1141/515 The article website is at: http://ijpt.iums.ac.ir/index.php/ijpt
    Publisher Link
    http://ijpt.iums.ac.ir/index.php/ijpt/article/view/1141/515
    Department
    Department of Pharmacy, BRAC University
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