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dc.contributor.authorRipa, Farhana Alam
dc.contributor.authorKhatun, Mst. Hajera
dc.contributor.authorNesa, Mst. Luthfun
dc.contributor.authorIslam, Rafikul
dc.contributor.authorAl mamum
dc.contributor.authorKadir, Shahin
dc.date.accessioned2016-11-21T08:27:44Z
dc.date.available2016-11-21T08:27:44Z
dc.date.issued2014-06
dc.identifier.citationKhatun, H., Nesa, L., Islam, R., Ripa, F. A., Mamum, A., & Kadir, S. (2014). Antidiabetic and antidiarrheal effects of the methanolic extract of phyllanthus reticulatus leaves in mice. Asian Pacific Journal of Reproduction, 3(2), 121-127. doi:10.1016/S2305-0500(14)60015-4en_US
dc.identifier.issn23050500
dc.identifier.urihttp://hdl.handle.net/10361/6887
dc.descriptionThis article was published in Asian Pacific Journal of Reproduction [© 2014 Elsevier (Singapore) Pte Ltd] and the definite version is available at: http://ac.els-cdn.com/S2305050014600154/1-s2.0-S2305050014600154-main.pdf?_tid=4cb9bd22-afc3-11e6-8aa5-00000aacb361&acdnat=1479716582_9ed93185b04db32d8b3df2c31398dc82 The article website is at: http://www.sciencedirect.com/science/journal/23050500en_US
dc.description.abstractObjective To assess the anti-diabetic and antidiarrheal activity of methanolic extract of Phyllanthus reticulates (P. reticulates) leaves in an animal model. Methods Phytochemical screening of methanolic extract of P. reticulatus leaves has been performed. Antidiabetic activity have been done by OGTT, normoglycemic hyperglycemia and alloxan induced diabetic mice. Plant extracts (150 mg/kg and 300 mg/kg, b.w.) were administered orally in fasting glucose loaded mice with regard to normal control and in alloxan induced (110 mg/kg body weight i.p.) diabetic mice in comparison with reference drug Metformin hydrochloride (100 mg/kg) during 7 day test period. Antidiarrheal test was conducted by castor oil and magnesium sulfate. Results Findings confirmed that the continuous post-treatment for 7 days with both extracts showed significant (P < 0.05) hypoglycemic activity in OGTT, normoglycemic and alloxan induced mouse models. Castor oil and Magnesium sulfate induced diarrheal test of the extract (200 and 400 mg/kg) has given significant effect in compairing to control diarrheal group. Conclusion Methanolic extract of P. reticulatus leaves have shown significant antidiabetic and antidiarrheal properties.en_US
dc.language.isoenen_US
dc.publisher© 2014 Elsevier (Singapore) Pte Ltden_US
dc.relation.urihttp://ac.els-cdn.com/S2305050014600154/1-s2.0-S2305050014600154-main.pdf?_tid=4cb9bd22-afc3-11e6-8aa5-00000aacb361&acdnat=1479716582_9ed93185b04db32d8b3df2c31398dc82
dc.subjectPhyllanthus reticulatusen_US
dc.subjectMethanolic extracten_US
dc.subjectHypoglycemic activityen_US
dc.subjectOGTTen_US
dc.subjectPhytochemicalen_US
dc.subjectAntidiarrhealen_US
dc.subjectCastor oilen_US
dc.subjectMagnesium sulfateen_US
dc.titleAntidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in miceen_US
dc.typeArticleen_US
dc.description.versionPublished
dc.contributor.departmentDepartment of Pharmacy, BRAC University


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