Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
Date
2014-06Publisher
© 2014 Elsevier (Singapore) Pte LtdAuthor
Ripa, Farhana AlamKhatun, Mst. Hajera
Nesa, Mst. Luthfun
Islam, Rafikul
Al mamum
Kadir, Shahin
Metadata
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Khatun, H., Nesa, L., Islam, R., Ripa, F. A., Mamum, A., & Kadir, S. (2014). Antidiabetic and antidiarrheal effects of the methanolic extract of phyllanthus reticulatus leaves in mice. Asian Pacific Journal of Reproduction, 3(2), 121-127. doi:10.1016/S2305-0500(14)60015-4Abstract
Objective
To assess the anti-diabetic and antidiarrheal activity of methanolic extract of Phyllanthus reticulates (P. reticulates) leaves in an animal model.
Methods
Phytochemical screening of methanolic extract of P. reticulatus leaves has been performed. Antidiabetic activity have been done by OGTT, normoglycemic hyperglycemia and alloxan induced diabetic mice. Plant extracts (150 mg/kg and 300 mg/kg, b.w.) were administered orally in fasting glucose loaded mice with regard to normal control and in alloxan induced (110 mg/kg body weight i.p.) diabetic mice in comparison with reference drug Metformin hydrochloride (100 mg/kg) during 7 day test period. Antidiarrheal test was conducted by castor oil and magnesium sulfate.
Results
Findings confirmed that the continuous post-treatment for 7 days with both extracts showed significant (P < 0.05) hypoglycemic activity in OGTT, normoglycemic and alloxan induced mouse models. Castor oil and Magnesium sulfate induced diarrheal test of the extract (200 and 400 mg/kg) has given significant effect in compairing to control diarrheal group.
Conclusion
Methanolic extract of P. reticulatus leaves have shown significant antidiabetic and antidiarrheal properties.
Keywords
Phyllanthus reticulatus; Methanolic extract; Hypoglycemic activity; OGTT; Phytochemical; Antidiarrheal; Castor oil; Magnesium sulfateDescription
This article was published in Asian Pacific Journal of Reproduction [© 2014 Elsevier (Singapore) Pte Ltd] and the definite version is available at: http://ac.els-cdn.com/S2305050014600154/1-s2.0-S2305050014600154-main.pdf?_tid=4cb9bd22-afc3-11e6-8aa5-00000aacb361&acdnat=1479716582_9ed93185b04db32d8b3df2c31398dc82 The article website is at: http://www.sciencedirect.com/science/journal/23050500Department
Department of Pharmacy, BRAC UniversityType
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