Show simple item record

dc.contributor.authorParvin, Salma
dc.contributor.authorIslam, Md. Siddiqul
dc.contributor.authorAl-Mamun, Mir Md. Abdullah
dc.contributor.authorIslam, Mohammad Safiqul
dc.contributor.authorAhmed, Maizbha Uddin
dc.contributor.authorKabir, Eva Rahman
dc.contributor.authorHasnat, Abul
dc.date.accessioned2016-11-09T07:06:58Z
dc.date.available2016-11-09T07:06:58Z
dc.date.copyright2016
dc.identifier.citationParvin, S., Islam, M. S., Al-Mamun, M. M. A., Islam, M. S., Ahmed, M. U., Kabir, E. R., & Hasnat, A. (2016). Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the bangladeshi population. Breast Cancer, , 1-9. doi:10.1007/s12282-016-0692-5
dc.identifier.issn13406868
dc.identifier.urihttp://hdl.handle.net/10361/6796
dc.descriptionThis article was published in Breast Cancer [© 2016 The Japanese Breast Cancer Society] and the definite version is available at: http://link.springer.com/article/10.1007/s12282-016-0692-5
dc.description.abstractPurpose: Breast cancer is considered as the most frequent female malignancy. Altered gene expressions due to genetic polymorphisms in the BRCA1, BRCA2, RAD51, and HER2 contribute toward the development of breast cancer, and yet, no such type of study has been conducted in the Bangladeshi population. This study was designed to evaluate the role of BRCA1rs80357713, BRCA1rs80357906, BRCA2rs11571653, RAD51rs1801320, and HER2rs1136201 polymorphisms as risk factors in the development of breast cancer in the Bangladeshi population. Methods: A total 310 patients with invasive breast cancers were recruited as cases from different public and private hospitals of Bangladesh, and 250 Bangladeshi healthy women matching age with the patients were recruited as controls. Polymerase chain reaction–restriction fragment length polymorphism method was used to analyze the genetic polymorphisms. Results: Patients carrying BRCA1/2 mutations, GC and GC plus CC genotypes of RAD51rs1801320, and AG plus GG genotype of HER2rs1136201 polymorphisms were found to be associated with breast cancer. In subgroup analysis, AG plus GG genotype of HER2rs1136201 was found to be associated with the breast cancer risk in the patients younger than 45 years of age compared with the older patients having more than 45 years of age, and RAD51rs1801320 was related to the tumor size and tumor aggressiveness (higher graded tumor). Conclusion: Our results indicate that BRCA1/BRCA2, RAD51rs1801320 and HER2rs1136201 polymorphisms were associated with breast cancer in the studied population.
dc.publisher© 2016 The Japanese Breast Cancer Societyen_US
dc.relation.urihttp://link.springer.com/article/10.1007/s12282-016-0692-5
dc.subjectBRCA1
dc.subjectBRCA2
dc.subjectBreast cancer
dc.subjectHER2
dc.subjectRAD51
dc.titleAssociation of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi populationen_US
dc.typeArticleen_US
dc.contributor.departmentDepartment of Pharmacy, BRAC University
dc.identifier.doi10.1007/s12282-016-0692-5


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record