dc.contributor.advisor | Hossain, Dr. M. Mahboob | |
dc.contributor.author | Raja, Abdul Al | |
dc.date.accessioned | 2015-09-23T06:22:16Z | |
dc.date.available | 2015-09-23T06:22:16Z | |
dc.date.copyright | 2015 | |
dc.date.issued | 2015-08 | |
dc.identifier.other | ID 11176003 | |
dc.identifier.uri | http://hdl.handle.net/10361/4439 | |
dc.description | This thesis report is submitted in partial fulfillment of the requirement for the degree of Masters of Science in Biotechnology, 2015. | en_US |
dc.description | Cataloged from PDF version of thesis report. | |
dc.description | Includes bibliographical references (page 58-61). | |
dc.description.abstract | Marbelus is an Unani Medicine of unique combination of Bael (Aegle marmelos) fruit and
Connessi (Holarrhena antidysenterica) bark, which is highly effective in diarrhoea, dysentery
(Amoebic & Bacillary dysentery), giardiasis and helminthiasis. However, toxicity study of the
Marbelus syrup is still lacking. The present study is to investigate the acute toxicity of Marbelus
Syrup extract on Sprague Dawley rats at a dose of 2000 mg/kg body weight (BW). Sighting
study was conducted in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg
BW. No signs of toxicity and no deaths were observed. Based on the sighting study, we selected
a dose of 2000 mg/kg BW and observed for 14 days. The study includes control and treatment
group, each consisting of 5 female rats. The single oral dose of the Marbelus syrup did not
produce mortality or significant changes in the body weight, food and water consumption. In the
female rats there was significant (p=0.045) increase (16.40%) in total protein where albumin
content was increased (1.56%) but not significantly (p=0.458) different from their corresponding
control values. The decrease in urea content (0.80% decrease; p=0.691) & uric acid content was
decreased by (12.54%; p=0.203) which was not statistically significant. The increase in both
HDL cholesterol content (10.13% increase; p=0.46) & total cholesterol content (14.89%
increase; p=0.23) was not statistically significant. It was observed that about 13.44% increase in
triglyceride content of treated female rats in comparison to their control female rats which was
statistically significant(p=0.030). However, total proteins were significantly increased indicating
dehydration. Apart from triglyceride, other biochemistry parameters demonstrated no significant
changes as compared to the control. | en_US |
dc.format.extent | 61 pages | |
dc.language.iso | en | en_US |
dc.publisher | BRAC University | en_US |
dc.subject | Biotechnology | en_US |
dc.subject | Department of mathematics and natural sciences | en_US |
dc.subject | Dysentery | en_US |
dc.subject | Unani Medicine | en_US |
dc.title | Study of acute toxicity of an unani medicine used in dysentery | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Department of Mathematical and Natural Science, BRAC University | |
dc.description.degree | M. Biotechnology | |