Study on bacteriological profile and antimicrobial susceptibility pattern in septicemia suspected patients

Abstract

Septicemia, a critical bloodstream infection, poses significant health challenges, particularly with the increasing prevalence of multidrug-resistant (MDR) pathogens. This study aimed to investigate bacterial isolates' bacteriological profile and antimicrobial susceptibility patterns from septicemia-suspected patients in Bangladesh. Fifty-six blood samples were analyzed, of which 33 (58.9%) tested positive for bacterial growth. The predominant pathogens identified were Klebsiella pneumoniae (75.8%), Staphylococcus aureus (12.1%), and Escherichia coli (12.1%). Most positive cases were observed in males (90.9%), with a significant age distribution among patients above 40. The eminence of antimicrobial susceptibility testing by Kirby Bauer disk diffusion method in sterile Muller Hinton Agar plates was done. The isolates efficacy and resistance profile was as follows: The highest resistance, 70 %, was seen against beta-lactams and fluoroquinolones, and carbapenems had better results than the other two drugs. These results also highlight the increasing threat from multi-drug resistance pathogens such as Klebsiella pneumoniae to warrant optimized and personalized antimicrobial stewardship. Thus, the present study underlines the essence of performing periodic scans of septicemia pathogens and resistance patterns, as the obtained data might be beneficial when developing guidelines and creating corresponding approaches in empiric treatment and public health. Large-scale population-based studies and the utilization of improved molecular approaches are encouraged for further research to build up the research findings and to eradicate the increasing menace of septicemia in Bangladesh. "