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dc.contributor.advisorSiam. Mohammad Kawsar Sharif
dc.contributor.authorTasnim, Jarin
dc.date.accessioned2024-10-30T08:29:55Z
dc.date.available2024-10-30T08:29:55Z
dc.date.copyright©2023
dc.date.issued2023-02
dc.identifier.otherID 18346012
dc.identifier.urihttp://hdl.handle.net/10361/24475
dc.descriptionThis thesis is submitted in partial fulfilment of the requirements for the degree of Bachelor of Pharmacy, 2022.en_US
dc.descriptionCatalogued from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 26-31).
dc.description.abstractHerpes zoster virus is a member of Alphaherpesvirinae subfamily and genus Varicellovirus of herpesviridae. Herpes zoster virus or Shingles is a viral disease. Recently, people are more suffering due to this virus. The varicella zoster virus (VZV), which also causes chickenpox, is what causes shingles. The initial virus infection in chickenpox, also known as varicella, often takes place during childhood or adolescence. There is only live attenuated vaccine for treating HZV and there are some antiviral drugs which are effective in early stage of this disease. But there is no promising in silico based vaccine for HZV. In this study, construction of herpes zoster vaccine through in silico method has been proposed against herpes zoster virus envelop glycoprotein E interferons. From UniProt database server Glycoprotein E sequence has been retrieved in FASTA file. Consequently, some online server are utilized to determine CTL, HTL and B-cell epitopes and other predictions. During study, a CTL , a HTL and a b-cell epitope shows best antigenic score and high inducing affinity with that herpes zoster glycoprotein E. The antigenicity rise happens from 0.51 to 0.53 when all antigenic epitopes are added in the construction. Z score, C-score ,GRAVY score are positive. The protein is hydrophilic which indicates it can be a good developed vaccine.en_US
dc.description.statementofresponsibilityJarin Tasnim
dc.format.extent52 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectIn silico methoden_US
dc.subjectToll-like receptoren_US
dc.subjectHerpes zoster Virusen_US
dc.subjectComputational methoden_US
dc.subject.lcshVaccines.
dc.subject.lcshHerpes Zoster--Immunology.
dc.titleConstruction of vaccine against Herpes Zoster Virus Glycoprotein E using In-silico methoden_US
dc.typeThesisen_US
dc.contributor.departmentSchool of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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