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dc.contributor.advisorSiam, Mohammad Kawsar Sharif
dc.contributor.authorSiddika, Samira
dc.date.accessioned2024-10-01T04:37:36Z
dc.date.available2024-10-01T04:37:36Z
dc.date.copyright©2024
dc.date.issued2024-04
dc.identifier.otherID 20146058
dc.identifier.urihttp://hdl.handle.net/10361/24264
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.en_US
dc.descriptionCataloged from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 37-39).
dc.description.abstractHantavirus is a zoonotic virus which is responsible for causing hemorrhagic fever with renal syndrome & hantavirus pulmonary syndrome. But still, there is no stable vaccine developed for this virus. Developing a multiepitope vaccine candidate against this virus was the main concern of this study by using immune-informative approach. Different computational tools were used to identify the CTL, HTL & B cell epitopes for envelope surface glycoprotein. Various linkers were used to connect the epitopes with the adjuvant and construct the candidate vaccine. Physicochemical properties like - molecular weight, instability index, aliphatic index, GRAVY was also checked for the prepared vaccine. Molecular docking was done with toll-like receptor 4 (TLR-4) for checking the residual interaction. And lastly, C-ImmSim was used to evaluate the immune stimulation. Further investigation is needed to check the safety and efficacy of this vaccine candidate because checking safety & efficacy is not a part of in-silico study.en_US
dc.description.statementofresponsibilitySamira Siddika
dc.format.extent51 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectHantavirusen_US
dc.subjectEnvelope glycoproteinen_US
dc.subjectHTLen_US
dc.subjectCTLen_US
dc.subjectB cellen_US
dc.subjectIn-silicoen_US
dc.subject.lcshHantavirus infections--Prevention.
dc.subject.lcshHantaviruses--Vaccines.
dc.titleIn-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirusen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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