dc.contributor.advisor | Siam, Mohammad Kawsar Sharif | |
dc.contributor.author | Siddika, Samira | |
dc.date.accessioned | 2024-10-01T04:37:36Z | |
dc.date.available | 2024-10-01T04:37:36Z | |
dc.date.copyright | ©2024 | |
dc.date.issued | 2024-04 | |
dc.identifier.other | ID 20146058 | |
dc.identifier.uri | http://hdl.handle.net/10361/24264 | |
dc.description | This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024. | en_US |
dc.description | Cataloged from PDF version of thesis. | |
dc.description | Includes bibliographical references (pages 37-39). | |
dc.description.abstract | Hantavirus is a zoonotic virus which is responsible for causing hemorrhagic fever with renal syndrome & hantavirus pulmonary syndrome. But still, there is no stable vaccine developed for this virus. Developing a multiepitope vaccine candidate against this virus was the main concern of this study by using immune-informative approach. Different computational tools were used to identify the CTL, HTL & B cell epitopes for envelope surface glycoprotein. Various linkers were used to connect the epitopes with the adjuvant and construct the candidate vaccine. Physicochemical properties like - molecular weight, instability index, aliphatic index, GRAVY was also checked for the prepared vaccine. Molecular docking was done with toll-like receptor 4 (TLR-4) for checking the residual interaction. And lastly, C-ImmSim was used to evaluate the immune stimulation. Further investigation is needed to check the safety and efficacy of this vaccine candidate because checking safety & efficacy is not a part of in-silico study. | en_US |
dc.description.statementofresponsibility | Samira Siddika | |
dc.format.extent | 51 pages | |
dc.language.iso | en | en_US |
dc.publisher | Brac University | en_US |
dc.rights | Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. | |
dc.subject | Hantavirus | en_US |
dc.subject | Envelope glycoprotein | en_US |
dc.subject | HTL | en_US |
dc.subject | CTL | en_US |
dc.subject | B cell | en_US |
dc.subject | In-silico | en_US |
dc.subject.lcsh | Hantavirus infections--Prevention. | |
dc.subject.lcsh | Hantaviruses--Vaccines. | |
dc.title | In-silico based multiepitope vaccine construction of envelope glycoprotein against Hantavirus | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Department of Pharmacy, Brac University | |
dc.description.degree | B. Pharmacy | |