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dc.contributor.advisorKhair, Nishat Zareen
dc.contributor.authorKhushbu, Samia Sajnin
dc.date.accessioned2024-10-01T03:57:03Z
dc.date.available2024-10-01T03:57:03Z
dc.date.copyright©2024
dc.date.issued2024-03
dc.identifier.otherID 19346013
dc.identifier.urihttp://hdl.handle.net/10361/24255
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2024.en_US
dc.descriptionCataloged from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 42-56).
dc.description.abstractThe Aurora kinases, comprising Aurora A, Aurora B, and Aurora C, constitute a family of serine/threonine protein kinases that plays a fundamental role in ensuring precise mitotic progression, regulating multiple phases of cell division, and maintaining genomic stability. The purpose of this review work is to provide an updated assessment of Aurora Kinase Inhibitors (AKIs) and their role as promising anticancer agents. Additionally, this article compiles the recent advancements in AKI research, encompassing novel compounds, their mechanisms of action, and preclinical/clinical trial outcomes. Aurora A regulates the process of maturation and separation of centrosomes, whereas Aurora B is responsible for ensuring precise chromosomal segregation. The significant correlation between the progression of malignancy and the dysregulation of Aurora kinases highlights their suitability as targets for pharmacological intervention, thereby making them a very promising area of emphasis for the creation of potent and specific anticancer drugs.en_US
dc.description.statementofresponsibilitySamia Sajnin Khushbu
dc.format.extent68 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectAurora kinasesen_US
dc.subjectKinase inhibitionen_US
dc.subjectSmall-molecule inhibitorsen_US
dc.subjectAnticancer agentsen_US
dc.subject.lcshAntineoplastic agents.
dc.subject.lcshCancer--Treatment.
dc.subject.lcshProtein kinases--Inhibitors--Therapeutic use.
dc.titleA current insight into Aurora kinase inhibitors and their potential as anticancer agentsen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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