dc.contributor.advisor | Ripa, Farhana Alam | |
dc.contributor.author | Lubaba, Rafiya Rafa | |
dc.date.accessioned | 2024-08-22T04:37:42Z | |
dc.date.available | 2024-08-22T04:37:42Z | |
dc.date.copyright | ©2023 | |
dc.date.issued | 2023-08 | |
dc.identifier.other | ID 19346050 | |
dc.identifier.uri | http://hdl.handle.net/10361/23863 | |
dc.description | This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. | en_US |
dc.description | Cataloged from the PDF version of thesis. | |
dc.description | Includes bibliographical references (pages 28-34). | |
dc.description.abstract | The study explored the analgesic and CNS depressant activities of a methanolic shell extract
from Nypa fruticans Wurmb fruit. Methanolic shell extract of N. fruticans Wurmb fruit was
acetic acid induced technique was used to test the analgesic efficacy in mice. An evaluation of CNS depressant activity used the hole cross test. Different doses (200, 400, and 600 mg/kg) were administered to mice, and results indicated significant dose-dependent analgesic and CNS depressant activities (p<0.05). The extract exhibited enhanced analgesic effects, achieving 51.16% inhibition at 600 mg/kg, whereas the standard drug Indomethacin achieved 79.54% inhibition. At 600 mg/kg, the extract reduced locomotor activity and exploratory behavior, similar to standard drug diazepam. These findings highlighted the notable analgesic and CNS depressant activities of the methanolic shell extract from N. fruticans Wurmb fruit. | en_US |
dc.description.statementofresponsibility | Rafiya Rafa Lubaba | |
dc.format.extent | 47 pages | |
dc.language.iso | en | en_US |
dc.publisher | Brac University | en_US |
dc.rights | Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. | |
dc.subject | Nypa fruticans | en_US |
dc.subject | Wurmb fruit | en_US |
dc.subject | Analgesic | en_US |
dc.subject | CNS depressant | en_US |
dc.subject | Hole cross method | en_US |
dc.subject.lcsh | Central nervous system depressants | |
dc.subject.lcsh | Analgesics--Toxicology | |
dc.title | Analgesic and CNS depressant activities of methanolic shell extract of Nypa fruticans Wurmb fruit in Swiss albino mice | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | School of Pharmacy, Brac University | |
dc.description.degree | B. Pharmacy | |