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dc.contributor.advisorHossain, M. Mahboob
dc.contributor.authorSaiyara, Fabiha
dc.contributor.authorHussain, Humyra Binte
dc.date.accessioned2024-08-14T06:28:08Z
dc.date.available2024-08-14T06:28:08Z
dc.date.copyright2024
dc.date.issued2024-04
dc.identifier.otherID 19236005
dc.identifier.otherID 19236019
dc.identifier.urihttp://hdl.handle.net/10361/23770
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Biotechnology, 2024.en_US
dc.descriptionCatalogued from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 51-55).
dc.description.abstractPlants have been used throughout history in traditional medicine, and remain a promising source of pharmaceuticals. Spondias mombin, an ethnomedicinal plant recognized for its efficacy in treating various diseases, is also the source of numerous therapeutic agents. Previous studies on the bark of this plant revealed its abundance of beneficial compounds along with several pharmacological properties. Although widely available in Bangladesh, limited scientific studies have been reported on this plant. Therefore, this thesis aims to investigate the antibacterial and antioxidant activity of locally sourced S. mombin stem bark extracts. The ethanolic bark extract was subjected to solvent partitioning with chloroform, ethyl acetate, hexane, and methanol. Then thin-layer chromatography, Kirby-Bauer disk diffusion test, and DPPH free radical scavenging assay were conducted on the solvent partitions. The ethyl acetate partition extract exhibited mild antibacterial activity against Acinetobacter baumanni ATCC 19606, E. coli ATCC 25922, Klebsiella pneumonia and Salmonella typhi. Additionally, all four partition extracts displayed very strong antioxidant activities, with the ethyl acetate extract demonstrating the strongest activity and the lowest IC50 value of 4.74 μg/mL. Visualization of the TLC plates showed the presence of several compounds in the chloroform, hexane, and ethyl acetate partitions which may be of medicinal value. Therefore, these findings underscore the importance of further research into this plant for therapeutic purposes.en_US
dc.description.statementofresponsibilityFabiha Saiyara
dc.description.statementofresponsibilityHumyra Binte Hussain
dc.format.extent55 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectSpondias mombinen_US
dc.subjectAntibacterialen_US
dc.subjectAntioxidanten_US
dc.subjectThin layer chromatographyen_US
dc.subjectDisk diffusionen_US
dc.subjectDPPH assayen_US
dc.subject.lcshBiotechnology
dc.titleDetermination of antibacterial and antioxidant activity of Spondias mombin stem bark extractsen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Mathematics and Natural Sciences, Brac University
dc.description.degreeB. Biotechnology


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