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dc.contributor.advisorSharmin, Sabrina
dc.contributor.authorZaman, Rubaiyat
dc.date.accessioned2024-06-05T08:30:25Z
dc.date.available2024-06-05T08:30:25Z
dc.date.copyright©2023
dc.date.issued2023-02
dc.identifier.otherID: 19146031
dc.identifier.urihttp://hdl.handle.net/10361/23157
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.en_US
dc.descriptionCataloged from the PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 54-61).
dc.description.abstractEpigenetics is of great importance to modern neuroscience because of its link to the etiology of certain neurodegenerative diseases. The roles of epigenetic changes like DNA methylation and histone acetylation in transcriptional control and dysregulation have been extensively investigated. DNA hypo methylation in Alzheimer's disease leads to elevated presenilin 1 expression, which in turn increases amyloid beta peptide deposition. Increased -synuclein expression and accumulated SNCA protein are hallmarks of Parkinson's disease, which is caused by aberrant methylation. Mutant Huntingtin causes transcriptional dysregulations in Huntington's disease by inhibiting histone acetyltransferases. This project paper reviews on the topic of epigenetics and neurodegeneration and discuss the role that how epigenetic dysregulation plays in the onset of these diseases and offer some insight into the therapeutic potential of epigenetics-based approaches.en_US
dc.description.statementofresponsibilityRubaiyat Zaman
dc.format.extent77 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectEpigeneticsen_US
dc.subjectMethylationen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectHuntington’s diseaseen_US
dc.subjectAcetylationen_US
dc.subject.lcshNervous System Diseases
dc.subject.lcshEpigenesis
dc.titlePotential treatments for epigenetic dysregulation in neurological diseasesen_US
dc.typeThesisen_US
dc.contributor.departmentSchool of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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