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dc.contributor.advisorSharmin, Sabrina
dc.contributor.authorRitu, Fariha Akhter
dc.date.accessioned2024-06-04T03:27:14Z
dc.date.available2024-06-04T03:27:14Z
dc.date.copyright2023
dc.date.issued2023-04
dc.identifier.otherID 18346079
dc.identifier.urihttp://hdl.handle.net/10361/23101
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.en_US
dc.descriptionCataloged from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 40-41).
dc.description.abstractA conserved catabolic process called autophagy involves the recycling of cytosolic organelles or components via a lysosome-dependent pathway. A number of disorders, such as Alzheimer's disease, Parkinson's disease, and cancer, are linked to abnormalities in autophagy. According to the current theory, autophagy appears to act as a tumor suppressor during the early stages of the development of cancer, but as the disease progresses, autophagy may promote and/or assist the growth and spread of the tumor as well as make it more resistant to treatment. Autophagy is therefore regarded as a stagedependent dual player in cancer. Endogenous non-coding short RNAs called microRNAs (miRNAs) control posttranscriptional gene expression in a negative manner.Additionally, mounting evidence from the literature suggests that dysregulation of miRNA expression affects how cancer forms, invades, metastasizes, and responds to chemotherapy or radiotherapy. As a result, research on autophagy-regulating miRNA in cancer will aid in the creation of new disease indicators and therapeutic approaches as well as a better understanding of malignancies given the significance of autophagy for cancer biology. Several of these cancer-related miRNAs may be studied since they have a role in controlling autophagy. We will concentrate on autophagy, miRNA, risk factors, cancer diagnosis, and cancer treatment in this review.en_US
dc.description.statementofresponsibilityFariha Akhter Ritu
dc.format.extent41 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectTumor suppressoren_US
dc.subjectEndogenousen_US
dc.subjectMicroRNAen_US
dc.subjectTranscriptional gene expressionen_US
dc.subjectDysregulationen_US
dc.subjectRadiotherapyen_US
dc.subjectChemotherapyen_US
dc.subjectMalignacyen_US
dc.subjectCytosolic organellesen_US
dc.subject.lcshCancer research.
dc.subject.lcshHuman physiology.
dc.subject.lcshCell physiology.
dc.titleA review on regulation of autophagy by microRNA in human breast canceren_US
dc.typeThesisen_US
dc.contributor.departmentSchool of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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