dc.contributor.advisor | Sharmin, Sabrina | |
dc.contributor.author | Ritu, Fariha Akhter | |
dc.date.accessioned | 2024-06-04T03:27:14Z | |
dc.date.available | 2024-06-04T03:27:14Z | |
dc.date.copyright | 2023 | |
dc.date.issued | 2023-04 | |
dc.identifier.other | ID 18346079 | |
dc.identifier.uri | http://hdl.handle.net/10361/23101 | |
dc.description | This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023. | en_US |
dc.description | Cataloged from PDF version of thesis. | |
dc.description | Includes bibliographical references (pages 40-41). | |
dc.description.abstract | A conserved catabolic process called autophagy involves the recycling of cytosolic organelles or components via a lysosome-dependent pathway. A number of disorders, such as Alzheimer's disease, Parkinson's disease, and cancer, are linked to abnormalities in autophagy. According to the current theory, autophagy appears to act as a tumor suppressor during the early stages of the development of cancer, but as the disease progresses, autophagy may promote and/or assist the growth and spread of the tumor as well as make it more resistant to treatment. Autophagy is therefore regarded as a stagedependent dual player in cancer. Endogenous non-coding short RNAs called microRNAs (miRNAs) control posttranscriptional gene expression in a negative manner.Additionally, mounting evidence from the literature suggests that dysregulation of miRNA expression affects how cancer forms, invades, metastasizes, and responds to chemotherapy or radiotherapy. As a result, research on autophagy-regulating miRNA in cancer will aid in the creation of new disease indicators and therapeutic approaches as well as a better understanding of malignancies given the significance of autophagy for cancer biology. Several of these cancer-related miRNAs may be studied since they have a role in controlling autophagy. We will concentrate on autophagy, miRNA, risk factors, cancer diagnosis, and cancer treatment in this review. | en_US |
dc.description.statementofresponsibility | Fariha Akhter Ritu | |
dc.format.extent | 41 pages | |
dc.language.iso | en | en_US |
dc.publisher | Brac University | en_US |
dc.rights | Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. | |
dc.subject | Tumor suppressor | en_US |
dc.subject | Endogenous | en_US |
dc.subject | MicroRNA | en_US |
dc.subject | Transcriptional gene expression | en_US |
dc.subject | Dysregulation | en_US |
dc.subject | Radiotherapy | en_US |
dc.subject | Chemotherapy | en_US |
dc.subject | Malignacy | en_US |
dc.subject | Cytosolic organelles | en_US |
dc.subject.lcsh | Cancer research. | |
dc.subject.lcsh | Human physiology. | |
dc.subject.lcsh | Cell physiology. | |
dc.title | A review on regulation of autophagy by microRNA in human breast cancer | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | School of Pharmacy, Brac University | |
dc.description.degree | B. Pharmacy | |