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dc.contributor.advisorKhan, Tanisha Tabassum Sayka
dc.contributor.authorMostofa, Golam
dc.date.accessioned2022-09-26T06:25:04Z
dc.date.available2022-09-26T06:25:04Z
dc.date.copyright2022
dc.date.issued2022-04
dc.identifier.otherID 18146021
dc.identifier.urihttp://hdl.handle.net/10361/17309
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.en_US
dc.descriptionCataloged from PDF version of thesis report.
dc.descriptionIncludes bibliographical references (pages 56-63).
dc.description.abstractEpigenetics holds significant relevance in the contemporary neuroscience and has been associated with the pathogenesis of different neurodegenerative disorders. Epigenetic modifications including DNA methylation and histone acetylation have been widely studied in context of transcriptional regulation and dysregulation. In Alzheimer’s disease, presenilin 1 expression is significantly increased from DNA hypomethylation, thereby increasing the amyloid β peptide deposition. In Parkinson’s disease, decreased methylation increases the expression of α-synuclein and leads to SNCA protein accumulation. In Huntington’s disease, mutant Huntingtin reduces the functioning of histone acetyltransferases, resulting in the transcriptional dysregulations. In this literature review, the role of epigenetic deregulation in the development of neurodegenerative disorders was discussed followed by an insight on the potential of epigenetics-based treatment for these neurodegenerative disorders.en_US
dc.description.statementofresponsibilityGolam Mostofa
dc.format.extent63 pages
dc.language.isoenen_US
dc.publisherBrac Universityen_US
dc.rightsBrac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission.
dc.subjectEpigeneticsen_US
dc.subjectDysregulationen_US
dc.subjectMethylationen_US
dc.subjectAcetylationen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectHuntington’s diseaseen_US
dc.subjectEpidrugsen_US
dc.titleEpigenetic dysregulation in neurodegenerative diseases and potential treatmenten_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Pharmacy, Brac University
dc.description.degreeB. Pharmacy


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