dc.contributor.advisor | Khan, Tanisha Tabassum Sayka | |
dc.contributor.author | Mostofa, Golam | |
dc.date.accessioned | 2022-09-26T06:25:04Z | |
dc.date.available | 2022-09-26T06:25:04Z | |
dc.date.copyright | 2022 | |
dc.date.issued | 2022-04 | |
dc.identifier.other | ID 18146021 | |
dc.identifier.uri | http://hdl.handle.net/10361/17309 | |
dc.description | This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022. | en_US |
dc.description | Cataloged from PDF version of thesis report. | |
dc.description | Includes bibliographical references (pages 56-63). | |
dc.description.abstract | Epigenetics holds significant relevance in the contemporary neuroscience and has been associated with the pathogenesis of different neurodegenerative disorders. Epigenetic modifications including DNA methylation and histone acetylation have been widely studied in context of transcriptional regulation and dysregulation. In Alzheimer’s disease, presenilin 1 expression is significantly increased from DNA hypomethylation, thereby increasing the amyloid β peptide deposition. In Parkinson’s disease, decreased methylation increases the expression of α-synuclein and leads to SNCA protein accumulation. In Huntington’s disease, mutant Huntingtin reduces the functioning of histone acetyltransferases, resulting in the transcriptional dysregulations. In this literature review, the role of epigenetic deregulation in the development of neurodegenerative disorders was discussed followed by an insight on the potential of epigenetics-based treatment for these neurodegenerative disorders. | en_US |
dc.description.statementofresponsibility | Golam Mostofa | |
dc.format.extent | 63 pages | |
dc.language.iso | en | en_US |
dc.publisher | Brac University | en_US |
dc.rights | Brac University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. | |
dc.subject | Epigenetics | en_US |
dc.subject | Dysregulation | en_US |
dc.subject | Methylation | en_US |
dc.subject | Acetylation | en_US |
dc.subject | Alzheimer’s disease | en_US |
dc.subject | Parkinson’s disease | en_US |
dc.subject | Huntington’s disease | en_US |
dc.subject | Epidrugs | en_US |
dc.title | Epigenetic dysregulation in neurodegenerative diseases and potential treatment | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Department of Pharmacy, Brac University | |
dc.description.degree | B. Pharmacy | |